Water → 1-Acetyl-4-(4-hexyloxyphenyl)piperazine

HRID 351546ノート

反応式

HRID 351546 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C(=O)(O)[O-].[K+].Br[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].O>CS(C)=O.C(OCC)(=O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

7

反応物 4

HCID 962WaterHCID 81011-BromohexaneHCID 516893Potassium BicarbonateHCID 7124411-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

生成物 1

HCID 227132431-Acetyl-4-(4-hexyloxyphenyl)piperazine

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

To a suspension of 1-acetyl-4-(4-hydroxyphenyl) piperazine (20 g) and potassium bicarbonate (12.55 g) in dimethylsulfoxide (200 ml) was added 1-bromohexane (19.12 ml) and stirred for 24 hours at 80° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over is magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-hexyloxyphenyl)piperazine (14.5 g).

後処理

  1. customdried
  2. filtrationThe magnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-55960f6b25f8486b9db79f648a9dc4ae
出典データセット
uspto-grants-2004_06
特許番号
US06743776B2

反応ノート

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