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HRID 351833作成日：2026年10月26日
Dimethyl-p-toluidine → 2-Chloro-4-(2,4-dimethoxy-benzyl)-7-methyl-3,4-dihydro-benzo[e][1,4]diazepin-5-one
https://huagongshe.com/reaction/351833
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl-p-toluidine | HCID 7471 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione | HCID 22713527 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Chloro-4-(2,4-dimethoxy-benzyl)-7-methyl-3,4-dihydro-benzo[e][1,4]diazepin-5-one | HCID 22713471 | — |
反応手順
4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (34.0 g, 100 mmol) and N,N-dimethyl-p-toluidine (28.9 mL, 200 mmol) were mixed in toluene (100 mL) and heated to 100° C. Then phosphorus oxychloride (10.1 mL, 110 mmol) was added dropwise and heating at 100° C. was continued for 2.5 h. The resulting dark red solution was used directly in the subsequent step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06743789B2 |
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| 出典データセット | uspto-grants-2004_06 |
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| ORD ID | ord-6064c7e3293a48e999426f7cafe2ad4c |
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| 出典メモ | uspto-grants-2004_06 |
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