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Potassium Carbonate → Ethyl 3-phenyl-3-[6-(4-hydroxybutoxy)indol-3-yl]propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromobutanol | HCID 118388 | — |
| 反応物 | Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate | HCID 15549281 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Ethyl 3-phenyl-3-[6-(4-hydroxybutoxy)indol-3-yl]propionate | HCID 22714487 | — |
反応手順
Analogously to Example 1.4, 1.2 g (3.88 mmol) of ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate are reacted with 1.16 g (7.6 mmol) of 4-bromo-1-butanol in the presence of 2.1 g (15.2 mmol) of potassium carbonate in 30 ml of acetone, giving ethyl 3-phenyl-3-[6-(4-hydroxybutoxy)indol-3-yl]propionate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06743810B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-bdbe467bff3347989743f13f1d11a32d |
| 出典メモ | uspto-grants-2004_06 |