Triethylamine → HCID 22714422、化合物

HRID 351933ノート

反応式

HRID 351933 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.Br.CC1C([C:22]2[NH:23][CH2:24][CH2:25][N:26]=2)=C(C)NN=1.C(N(CC)CC)C>CN(C=O)C>[NH:26]1[CH2:25][CH2:24][N:23]=[C:22]1[NH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 22714433HCID 22714433、化合物HCID 534351342-(3,5-Dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide

生成物 1

HCID 22714422HCID 22714422、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

500 mg (2.6 mmol) of 6-(3-aminopropoxy)indole 23 [prepared in accordance with Example 9.1] are dissolved in 10 ml of DMF together with 0.97 g (3.9 mmol) of 2-(3,5-dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide and 1.7 ml (11.9 mmol) of triethylamine, and the solution is stirred at 60° C. for 12 hours. After the solution has been evaporated, the crude product is purified by preparative HPLC.

後処理

  1. customAfter the solution has been evaporated
  2. customthe crude product is purified by preparative HPLC

出典と根拠

ORDレコード
ord-4e580d69350a4fb78f11816bd2b49ae8
出典データセット
uspto-grants-2004_06
特許番号
US06743810B2

反応ノート

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