反応式
[C-:1]#[N:2].[Na+].O.Cl[CH2:6][C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[CH2:12])=[CH:9][CH:8]=1>C(O)C>[C:1]([CH2:6][C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[CH2:12])=[CH:9][CH:8]=1)#[N:2]参加物
反応条件
- 温度
- 65 °C
実験手順
In a 500 μl 4-opening flask equipped with a stirring bar, 49.01 g of sodium cyanide was mixed with 70.07 g of water and 50.96 g of ethanol. Then, the temperature of the flask was elevated to 60° C. and the sodium cyanide was completely dissolved. To said solution; 87.50 g of 4-chloromethylstyrene was slowly added and it was reacted for 3 hours while stirring and maintaining the reaction temperature within 60-70° C. When the reaction terminated, said solution was cooled to 40° C., and 100 g of diethylether was added and the diethylether layer was separated. The separated organic layer was extracted with 300 g of water three times, and the water layer was extracted with 50 g of diethylether and was combined with said organic layer. The separated obtained organic layer was dried with magnesium sulfate for one day, and then the organic solvent was removed using an evaporator to obtain the product 4-cyanomethylstyrene. The yield of the product was 80%, and the product was a deep purple color.
後処理
- customIn a 500 μl 4-opening flask equipped with a stirring bar
- customwas elevated to 60° C.
- customit was reacted for 3 hours
- customWhen the reaction terminated
- temperaturewas cooled to 40° C.
- addition100 g of diethylether was added
- customthe diethylether layer was separated
- extractionThe separated organic layer was extracted with 300 g of water three times
- extractionthe water layer was extracted with 50 g of diethylether
- customThe separated obtained organic layer
- dry with materialwas dried with magnesium sulfate for one day
- customthe organic solvent was removed
- customan evaporator
出典と根拠
- ORDレコード
- ord-a8346eeaec8b442fa32c0a8747ac8cc9
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06743881B2
関連ノート
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