4-Chloro-2-hydroxybenzonitrile → [4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester

HRID 352142ノート

反応式

HRID 352142 の反応式
[CH3:1][C:2]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][CH2:10][CH:11]([OH:17])[C:12]1[S:13][CH:14]=[CH:15][N:16]=1)([CH3:4])[CH3:3].O[C:20]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:21]=1[C:22]#[N:23]>>[CH3:4][C:2]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][CH2:10][CH:11]([O:17][C:20]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:21]=1[C:22]#[N:23])[C:12]1[S:13][CH:14]=[CH:15][N:16]=1)([CH3:1])[CH3:3]

参加物

3

反応物 2

HCID 34427894-Chloro-2-hydroxybenzonitrileHCID 131724450[4-Hydroxy-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester

生成物 1

HCID 70153671[4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester

実験手順

The subtitle compound was prepared according to the method of Example 19 step (b) using the product of step (c) above and 2-hydroxy-4-chlorobenzonitrile.

出典と根拠

ORDレコード
ord-1c59f2ead2204902a9b7db3fc3e0ad46
出典データセット
uspto-grants-2004_06
特許番号
US06743939B2

反応ノート

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