[4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester → 2-[4-Amino-1-(2-thiazolyl)butoxy]-4-chlorobenzonitrile hydrochloride

HRID 352143ノート

反応式

HRID 352143 の反応式
CC(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH:11]([O:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25]#[N:26])[C:12]1[S:13][CH:14]=[CH:15][N:16]=1)(C)C>Cl.O1CCOCC1>[ClH:24].[NH2:7][CH2:8][CH2:9][CH2:10][CH:11]([C:12]1[S:13][CH:14]=[CH:15][N:16]=1)[O:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25]#[N:26]

参加物

4

反応物 1

HCID 70153671[4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester

生成物 1

HCID 227151012-[4-Amino-1-(2-thiazolyl)butoxy]-4-chlorobenzonitrile hydrochloride収率 65.2%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

The product from step (d) (0.20 g) was dissolved in 4M hydrochloric acid in dioxan (5 ml) and stirred for 3hat room temperature. The solvent was evaporated and the residue triturated with dry diethyl ether to give the title compound as a pale yellow solid (0.055 g). M.p 170-172° C.

後処理

  1. customThe solvent was evaporated
  2. customthe residue triturated with dry diethyl ether

出典と根拠

ORDレコード
ord-a1d87e90e87f417188e4fd7110ca6653
出典データセット
uspto-grants-2004_06
特許番号
US06743939B2

反応ノート

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