化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → N-tert-Butylglycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Methyl 2-(tert-butylamino)acetate | HCID 2777439 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-tert-Butylglycine | HCID 414246 | — |
反応手順
To a solution of tert-Butylamino-acetic acid methyl ester (Maybridge), 122 mg (0.84 mmol) in 10 mL of dioxane was added a solution of 60 mg (2.52 mmol) of lithium hydroxide in 10 mL of water. The reaction mixture was stirred for two hours, acidified to pH=1 with 5 N HCl and concentrated to dryness to yield the crude desired product which was carried on without further purification. MS (IS) 132.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06743794B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-31f8addea56842a7a11d48ec765271ec |
| 出典メモ | uspto-grants-2004_06 |