Sodium Bicarbonate → 5-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one

HRID 352237ノート

反応式

HRID 352237 の反応式
I.[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([N:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:19])[C:13]=3[C:12]3=[N:20][O:21][C:22]([CH3:23])=[C:11]3[C:10]2=[O:24])[CH2:4]1.C([O-])(O)=O.[Na+]>>[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([N:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:19])[C:13]=3[C:12]3=[N:20][O:21][C:22]([CH3:23])=[C:11]3[C:10]2=[O:24])[CH2:4]1

参加物

3

反応物 2

HCID 516892Sodium BicarbonateHCID 227137135-(3-Aminocyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one hydroiodide

生成物 1

HCID 227137145-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one収率 98%

実験手順

A compound from Example 634 (350 mg,0.95 mmol) was treated with excess aqueous NaHCO3 and the mixture extracted with EtOAc. The combined extracts were dried over Na2SO4 and concentrated in vacuo to yield 309 mg (98%) of the title compound.

後処理

  1. extractionthe mixture extracted with EtOAc
  2. dry with materialThe combined extracts were dried over Na2SO4
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f1f4016b20b04d1a86714a40492d5889
出典データセット
uspto-grants-2004_06
特許番号
US06743794B2

反応ノート

読み込み中…