化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 2-(Chloromethyl)naphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Naphthalenemethanol | HCID 74128 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Chloromethyl)naphthalene | HCID 75632 | — |
反応手順
To 1.26 mol of naphth-2-yl-methanol in 1.5 liters of toluene there are slowly added 3.8 mol of thionyl chloride. The mixture is then heated at reflux for two hours. After cooling, the solvent is evaporated off. The crude product is taken up in toluene twice and evaporated. The oil obtained is taken up in dichloromethane, washed and dried. After filtering and evaporating, the oil obtained is distilled to yield the expected product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06747032B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-2b76a36fe9d8421e9983fe191e681c45 |
| 出典メモ | uspto-grants-2004_06 |