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cis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindoline → cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | cis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 69835917 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 11265480 | — |
反応手順
The title compound was prepared from D4 by hydrogenation over 10% Pd/C using a similar procedure to Example 45 (98%), followed by hydrolysis in 2M HCl using a similar procedure to Description 3 (80%) to afford the product as a pale brown solid
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06747030B1 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-7364dfedd8244a10939e58d2c4a3bb0e |
| 出典メモ | uspto-grants-2004_06 |