2-Fluoro-3-(trifluoromethyl)phenylacetic acid → HCID 44402887、化合物
反応式
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=O.[CH3:16][O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][C:26]=1[N:27]1[CH2:32][C@H:31]([CH3:33])[N:30]([CH3:34])[C@H:29]([CH3:35])[CH2:28]1)[NH:23][CH2:22][CH2:21]2>>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([N:23]1[C:24]2[C:20](=[CH:19][C:18]([O:17][CH3:16])=[C:26]([N:27]3[CH2:32][C@H:31]([CH3:33])[N:30]([CH3:34])[C@H:29]([CH3:35])[CH2:28]3)[CH:25]=2)[CH2:21][CH2:22]1)=[O:15]参加物
3
実験手順
The title compound was prepared from 2-fluoro-3-trifluoromethylphenylacetic acid (155 mg, 0.70 mmole) and D3 (150 mg, 0.54 mmole) using a similar procedure to Example 8. The product was obtained as a pale yellow oil (210 mg, 81%), which was converted to its hydrochloride salt as a beige solid.
出典と根拠
- ORDレコード
- ord-c5d20f0c98624bae96a6bcc57e721702
- 出典データセット
- uspto-grants-2004_06
- 特許番号