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Carbon Disulfide → 4-(Tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Disulfide | HCID 6348 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Butanoic acid, 4-chloro-, methyl ester | HCID 76612 | — |
| 反応物 | Tetrahydrofurfurylamine | HCID 253298 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester | HCID 9903733 | — |
反応手順
To a solution of tetrahydofurfurylamine (2 mL) in EtOH (20 mL) were added 5 N NaOH (3.9 mL) and carbon disulfide (1.17 mL), and the mixture was stirred for 1.5 h. Methyl 4-chlorobutyrate (2.4 mL) was then added, and the mixture was stirred overnight. Upon quenching with saturated NaCl solution the mixture was extracted with ether. Chromatography on silica gel gave the desired 4-(tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester product (1.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06747061B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-4bd9eb844c2a4b3f994ea8ed6e3ff0e7 |
| 出典メモ | uspto-grants-2004_06 |