化工社化工社 化学情報印刷レポート · 研究参考用
L-Hydroxyproline → 1-(Phenylmethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Hydroxyproline | HCID 5810 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 生成物 | 1-(Phenylmethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate | HCID 391517 | 58% |
反応手順
According to the literature procedure (J. Am. Chem. Soc. 189 (1957)), trans-4-hydroxy-L-proline (5.12 g, 0.039 mol) was treated with benzyl chloroformate (8.5 mL, 0.06 mol) to provide the title compound (6.0 g) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06747150B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-ef7a14e3470d461fb1641c7dd5af6295 |
| 出典メモ | uspto-grants-2004_06 |