Acetone → 259807-20-0

HRID 352736ノート

反応式

HRID 352736 の反応式
[ClH:1].CC(C)=O.C(OC([N:13]1[CH2:18][CH2:17][N:16]([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:15][CH2:14]1)=O)(C)(C)C>ClCCl.C(O)C>[ClH:1].[N:16]1([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]1

参加物

6

反応物 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 69700183HCID 69700183、化合物

生成物 1

HCID 22711429259807-20-0

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

In dichloromethane (2.5 ml), 2-[4-[[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide was dissolved. To the resulting solution, a saturated solution of hydrochloride in ethanol (2.5 ml) was added, followed by stirring at room temperature for 1 hour. After the solvent was distilled off under reduced pressure, water was added to the residue, whereby an aqueous solution was obtained. Acetone was added to the aqueous solution until the solution became turbid. The precipitate was collected by filtration and washed with acetone, whereby the title compound (274 mg, 81%) was obtained.

後処理

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added to the residue, whereby an aqueous solution
  3. customwas obtained
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with acetone, whereby the title compound (274 mg, 81%)
  6. customwas obtained

出典と根拠

ORDレコード
ord-53c7e3ae9c8842b384435d70f0881e39
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

反応ノート

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