HCID 178418287、化合物 → HCID 178453606、化合物

HRID 352741ノート

反応式

HRID 352741 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][OH:17])[CH2:12][CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]1[CH2:11][CH2:12][C@H:13]([CH:16]=[O:17])[CH2:14][CH2:15]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

参加物

4

反応物 2

HCID 178418287HCID 178418287、化合物HCID 178453607HCID 178453607、化合物

生成物 1

HCID 178453606HCID 178453606、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In dichloromethane (5 ml), trans-4-(N-tert-butoxycarbonylaminomethyl)cyclohexylmethanol (0.20 g) was dissolved, followed by the addition of pyridinium chlorochromate (0.23 g). The resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:1), whereby the title compound (0.15 g, 76%) was obtained.

後処理

  1. customThe reaction mixture was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:1), whereby the title compound (0.15 g, 76%)
  2. customwas obtained

出典と根拠

ORDレコード
ord-1fe0ad8f8cae41dda2d7ddd30b33cd97
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

反応ノート

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