4-Methylmorpholine → 4-Chloro-2-methoxybenzaldehyde

HRID 352835

反応式

HRID 352835 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([O:10][CH3:11])[CH:3]=1.CN1CCOCC1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([O:10][CH3:11])[CH:3]=1

参加物

5

反応物 2

HCID 79724-MethylmorpholineHCID 35493934 Chloro-2-methoxybenzyl alcohol

生成物 1

HCID 138651154-Chloro-2-methoxybenzaldehyde

試薬・触媒・溶媒 2

HCID 178419074HCID 178419074、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

In methylene chloride (80 ml) was dissolved (4-chloro-2-methoxyphenyl)methanol (3.69 g). Under ice cooling, molecular sieve 4A (4.57 g), N-methylmorpholine (2.81 g) and tetra-n-propylammonium perruthenate (420 mg) were added to the resulting solution, followed by stirring at room temperature for 2.5 hours. The reaction mixture was distilled under reduced pressure. The residue was subjected to chromatography on a silica gel column (hexane:ethyl acetate=9:1), whereby the title compound (3.07 g) was obtained as pale yellow oil.

後処理

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customwas obtained as pale yellow oil

出典と根拠

ORDレコード
ord-ad5fea9e0b5f4ceb8a3ddf1d9c72e567
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

関連ノート

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