4-Methylmorpholine → 4-Chloro-2-methoxybenzaldehyde
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([O:10][CH3:11])[CH:3]=1.CN1CCOCC1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([O:10][CH3:11])[CH:3]=1参加物
5
実験手順
In methylene chloride (80 ml) was dissolved (4-chloro-2-methoxyphenyl)methanol (3.69 g). Under ice cooling, molecular sieve 4A (4.57 g), N-methylmorpholine (2.81 g) and tetra-n-propylammonium perruthenate (420 mg) were added to the resulting solution, followed by stirring at room temperature for 2.5 hours. The reaction mixture was distilled under reduced pressure. The residue was subjected to chromatography on a silica gel column (hexane:ethyl acetate=9:1), whereby the title compound (3.07 g) was obtained as pale yellow oil.
後処理
- distillationThe reaction mixture was distilled under reduced pressure
- customwas obtained as pale yellow oil
出典と根拠
- ORDレコード
- ord-ad5fea9e0b5f4ceb8a3ddf1d9c72e567
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06747023B1
反応ノート
読み込み中…