Ammonia → HCID 9968829、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:11]([C:20]([O:22]CC)=O)=[N:12][N:13]([CH2:17][CH2:18][OH:19])[C:14]=2[CH2:15][CH3:16])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:11]([C:20]([NH2:25])=[O:22])=[N:12][N:13]([CH2:17][CH2:18][OH:19])[C:14]=2[CH2:15][CH3:16])[CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

反応物 2

HCID 222Ammonia

HCID 10200330Ethyl 4-[(3,5-dichlorophenyl)sulfanyl]-5-ethyl-1-(2-hydroxyethyl)-1H-pyrazole-3-carboxylate

生成物 1

HCID 9968829HCID 9968829、化合物

実験手順

A mixture of Example 46 (407 mg, 1.05 mmol) and 0.880 ammonia solution was heated at 90° C. in a sealed Reacti-vial (Trade Mark) for 18 hours. The precipitate was filtered off and washed with water (5 ml) to afford the title compound (273 mg) as a white solid, m.p. 214-216° C.

後処理

filtrationThe precipitate was filtered off
washwashed with water (5 ml)

出典と根拠

ORDレコード: ord-bc16002b460c4999afdc0949773f1713
出典データセット: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06750230B2

反応ノート

読み込み中…

参加物