Phenyl isocyanate → 4-(6,7-Dimethoxy-4-quinazolinyl)-N-phenyl-1-piperazinecarboxamide

HRID 353126

反応式

HRID 353126 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:16][CH2:17][N:18]([C:28]([NH:27][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:29])[CH2:19][CH2:20]1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 27584846,7-Dimethoxy-4-piperazin-1-yl-quinazoline

生成物 1

HCID 110366394-(6,7-Dimethoxy-4-quinazolinyl)-N-phenyl-1-piperazinecarboxamide収率 44.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 5 ml of ethanol was dissolved 278 mg (1.0 mmol) of 6,7-dimethoxy-4-piperazinylquinazoline obtained by the method described in South African Patent No. 67 06512 (1968), and 0.109 ml (1.0 mmol) of phenyl isocyanate was added thereto. The mixture was heated under reflux for 10 minutes and then allowed to cool to room temperature. The precipitated crystals were collected by filtration and recrystallized from ethanol to give 174.3 mg of the desired compound as colorless crystals. yield: 44%

後処理

  1. customobtained by the method
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for 10 minutes
  4. filtrationThe precipitated crystals were collected by filtration
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-5ffd5bb6f69f4aa7829f9648c102a026
出典データセット
uspto-grants-2004_06
特許番号
US06750218B2

関連ノート

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