Triethylamine → 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline

HRID 353130ノート

反応式

HRID 353130 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=1)=[O:23]>C(Cl)Cl>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH:11][C:22]([O:24][C:25]3[CH:26]=[CH:27][C:28]([N+:31]([O-:33])=[O:32])=[CH:29][CH:30]=3)=[O:23])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 821294-Nitrophenyl chloroformate

生成物 1

HCID 227075274-morpholino-N-(4-nitrophenoxycarbonyl)aniline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2.60 g (14.6 mmol) of 4-morpholinoaniline in 20 ml of methylene chloride were added 14.07 ml (105 mmol) of triethylamine and 3.53 g (17.5 mmol) of 4-nitrophenyl chloroformate under ice-cooling, followed by stirring at room temperature for 7 hours. After the solvent was evaporated, water was added to the residue, and the precipitated crystals were collected by filtration, washed water, and dried to give 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline.

後処理

  1. temperaturecooling
  2. customAfter the solvent was evaporated
  3. additionwater was added to the residue
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed water
  6. customdried

出典と根拠

ORDレコード
ord-3a7d66366e4f469389c1b27882ab0fdc
出典データセット
uspto-grants-2004_06
特許番号
US06750218B2

反応ノート

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