Ethanol → HCID 22708122、化合物

HRID 353218

反応式

HRID 353218 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH3:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=O.[OH-].[K+].C(O)C>O>[F:1][C:2]1[CH:3]=[C:4]([C:5](=[O:6])/[CH:10]=[CH:11]/[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 702EthanolHCID 99673-FluoroacetophenoneHCID 14797Potassium HydroxideHCID 680093-Fluorobenzaldehyde

生成物 1

HCID 22708122HCID 22708122、化合物収率 93%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 3-fluorobenzaldehyde (7.63 mL, 72.4 mmol), 3-fluoroacetophenone (10 g, 72.4 mmol), potassium hydroxide (5.18 g, 92.6 mmol), ethanol (23 mL) and water (47 mL) was stirred overnight at room temperature. After the reaction solution was diluted with water, the solid was collected by filtration and washed with ethanol and diethyl ether, to give the title compound (16.4 g, 93%).

後処理

  1. filtrationthe solid was collected by filtration
  2. washwashed with ethanol and diethyl ether

出典と根拠

ORDレコード
ord-1dc89752ecc94f6f816c4c7f12c5b1be
出典データセット
uspto-grants-2004_06
特許番号
US06750232B2

関連ノート

読み込み中…