Acetone → hexahydro-3,3-dimethylimidazo(1,5-a)pyrazin-1(5H)-one
反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH:2]1[C:7]([NH2:9])=[O:8].COCCO.[CH3:15][C:16](=O)[CH3:17]>>[CH3:15][C:16]1([CH3:17])[N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH:2]2[C:7](=[O:8])[NH:9]1参加物
4
実験手順
To a stirred and warm solution of 3 parts of 2-piperazinecarboxamide in 16 parts of 2-methoxyethanol were added 51.2 parts of 2-propanone. The whole was stirred and refluxed for 20 hours. The reaction mixture was evaporated. The solid residue was crystallized from acetonitrile, yielding 2.5 parts (64%) of hexahydro-3,3-dimethylimidazo[1,5-a]pyrazin-1(5H)-one; mp. 174.2° C. (intermediate 83).
後処理
- stirringThe whole was stirred
- temperaturerefluxed for 20 hours
- customThe reaction mixture was evaporated
- customThe solid residue was crystallized from acetonitrile
出典と根拠
- ORDレコード
- ord-ef198f70863b42b98e03e8b84832ef6a
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04766125
反応ノート
読み込み中…