関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 反応物 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Qing Hau Sau | HCID 9838675 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Dihydroartemisinin ethyl ether | HCID 72416 | 72.8% |
反応手順
Artemisinin (1 g.) and polyhydroxy catalyst, dextrose (4 g.) were stirred in ethanol (15 ml). Sodium borohydride (500 mg.) was added slowly for 10 minutes and the reaction mixture was stirred for 30 minutes at room temperature (20-23° C.). After completion of the reduction step, chlorotrimethysilane (3.5 ml) was added and the reaction mixture was further stirred for 1.5 hours at room temperature. After usual work up and purification through column chromatography (1:5 ratio) a mixture of alpha and beta arteether (0.805 g., 80.5% w/w) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06750356B1 |
|---|
| 出典データセット | uspto-grants-2004_06 |
|---|
| ORD ID | ord-291903af93754e7dade38971f634d5e8 |
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| 出典メモ | uspto-grants-2004_06 |
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