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DL-Carnitine → Tert-butyl acetyl carnitine chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | DL-Carnitine | HCID 288 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | Tert-butyl acetyl carnitine chloride | HCID 131715696 | 80% |
反応手順
Carnitine chloride (1.97 g; 0.01 moles) was dissolved in trifluoroacetic acid (10 cc). To the solution tert-butyl acetyl chloride (1.4 cc; 0.01 moles) was slowly added under stirring. The resulting mixture was kept under stirring at room temperature for 48 hours. To the mixture Et2O was added and the thus obtained precipitate was filtered off. The raw product was crystallized from isopropanol-ethyl ether, thus obtaining a pure product. MP 164°-165° C. Yield 80%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766222 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-02fba49a08984876a7c07be75ff83bf6 |
| 出典メモ | uspto-grants-1988_08 |