Bromine → 3-Fluoro-4-methoxyphenacyl bromide
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:10](=[O:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Br:13]Br>O1CCOCC1>[Br:13][CH2:11][C:10]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=1)=[O:12]参加物
4
実験手順
To a solution of 3′-fluoro-4′-methoxyacetophenone (1 g, 5.9 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (1.13 g, 7.1 mmol) in dioxane (30 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone as a white powder (910 mg, 63% yield).
後処理
- concentrationthe mixture was concentrated in vacuo
- customthe residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant
出典と根拠
- ORDレコード
- ord-9b6db527d6d14d4b8d3d3e03388a5698
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06756374B2
反応ノート
読み込み中…