Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

1. concentrationthe mixture was concentrated in vacuo
2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

ORDレコード

ord-0983911438fc4665b760dfdbb7ac7f37

出典データセット

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06756374B2