Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

HRID 353728

反応式

HRID 353728 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]

参加物

4

反応物 2

HCID 24408BromineHCID 5185963',5'-Difluoroacetophenone

生成物 1

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanone収率 64.3%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

出典と根拠

ORDレコード
ord-0983911438fc4665b760dfdbb7ac7f37
出典データセット
uspto-grants-2004_06
特許番号
US06756374B2

関連ノート

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