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DL-Carnitine → 4-Carbomethoxy butyryl carnitine chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | DL-Carnitine | HCID 288 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Methyl 4-chloroformylbutyrate | HCID 73916 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 4-Carbomethoxy butyryl carnitine chloride | HCID 131715702 | — |
反応手順
To a solution of carnitine chloride (2.0 g; 10 m moles) in TFA (5 cc), 4-carbomethoxy butyryl chloride (1.65 cc; 12 m moles) was added and the resulting reaction mixture was kept at room temperature under stirring for 24 hours. To this mixture anhydrous ethyl ether was then added. A solid formed which was filtered off and crystallized from hot isopropanol. M.P. 130°-132° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766222 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-96f8a0ff3c6b4f4ea6fcbcff987e883e |
| 出典メモ | uspto-grants-1988_08 |