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Cyanamide → 3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanamide | HCID 9864 | — |
| 反応物 | 3-(2-Bromoacetyl)benzonitrile | HCID 2735867 | — |
| 反応物 | 1-(4-Isothiocyanatophenyl)-4-(1-methylethyl)piperazine | HCID 9878386 | — |
| 生成物 | 3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile | HCID 21958907 | — |
反応手順
This compound was prepared from cyanamide, 1-(4-isothio-cyanatophenyl)-4-isopropypiperazine (of Example 3) and 3-cyanophenacyl bromide (Maybridge Chemical Co. Ltd.) following the procedure used in Example 24. Mass spectrum (ES) MH+=447.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756374B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-748c19b58f914be88183d232a5126ad1 |
| 出典メモ | uspto-grants-2004_06 |