DL-Carnitine → Ethoxy acetyl carnitine chloride

温度

80 °C

A mixture of ethoxy acetic acid (5 ml; 0.07 moles) and ethoxyacetyl chloride (1.8 ml; 0.015 moles) which had been prepared as disclosed in step (b) of Example 5, was kept under stirring for 2 hours at 80° C. To this mixture carnitine chloride (2 g; 0.01 moles) which had been previously dried was added. The resulting mixture was first kept at 80° C. until complete dissolution of carnitine took place, then at 40° C. for eight days. A further amount of ethoxyacetyl chloride (0.9 ml; 0.007 moles) was added and the resulting mixture was kept at 40° C. for seven days. Upon addition to the mixture of tert-butyl methyl ether an oil precipitated. The oil precipitation was repeated four times with acetonitrile/tert butyl methyl ether until complete removal of the ethoxyacetic acid in excess. 1.5 grams of the title compound were thus obtained. Yield: 75%

1. customhad been prepared
2. additionwas added
3. waitat 40° C. for eight days
4. waitthe resulting mixture was kept at 40° C. for seven days
5. additionUpon addition
6. customprecipitated
7. customThe oil precipitation
8. customuntil complete removal of the ethoxyacetic acid in excess

ORDレコード

ord-f5d28144541a4d72ab9b187af1c7add8

出典データセット

uspto-grants-1988_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04766222