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4-Iodo-1-tritylimidazole → 2-(1H-imidazol-4-yl)pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Iodo-1-tritylimidazole | HCID 618252 | — |
| 反応物 | 2-Bromopyrazine | HCID 642800 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 触媒 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(1H-imidazol-4-yl)pyrazine | HCID 178420761 | — |
反応手順
To a solution of 4-Iodo-1-trityl-1H-imidazole (1 eq) in THF at room temperature was added ethylmagnesium bromide (1.2 eq) under dry conditions. After stirring for 90 minutes, zinc chloride (1.2 eq) was added to the reaction mixture. After stirring for another 90 minutes, tetrakis(triphenylphosphine) palladium (10%) and 5-bromopyrazine (1.3 eq) were added to the reaction mixture. Subsequent reaction conditions and work up are as described previously in Example 73, the resulting solid 2-(1H-Imidazol-4-yl)-pyrazine (37%) was collected by filtration. MH+(147).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756359B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-2ffb63a6393a408bb6de2ae981e79900 |
| 出典メモ | uspto-grants-2004_06 |