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O-Phenylenediamine → ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Phenylenediamine | HCID 7243 | — |
| 反応物 | Ethyl 3-ethoxy-3-iminopropionate hydrochloride | HCID 75345 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate | HCID 308071 | — |
反応手順
A solution of 1,2-phenylenediamine (1.0 eq) and ethyl 3-ethoxy-3-iminopropanoate hydrochloride (1.3 eq) in EtOH was stirred at 90° C. overnight. The reaction was cooled to room temperature and the solvent removed in vacuo. Water and CH2Cl2 were added to the residue. The organic layer was separated, dried over Na2SO4 and the solvent removed. The solid recovered was used without purification. LC/MS m/z 205.2 (MH+), Rt 1.44 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756383B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-7ebd6310aecc423cba1434ab8eef2675 |
| 出典メモ | uspto-grants-2004_06 |