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Oxalyl chloride → 4-(Chloromethyl)benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-(Chloromethyl)benzoic acid | HCID 74234 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Chloromethyl)benzoyl chloride | HCID 70136 | — |
反応手順
Oxalyl chloride (4.4 mL of 2M in chloroform, 8.8 mmol) was added to a suspension of 4-(chloromethyl)benzoic acid (1 g, 5.7 mmol) in dichloromethane. N,N-dimethylformamide (4 drops) was added to catalyze the reaction. After 1 hour analysis by HPLC indicated 100% clean conversion. The reaction mixture was concentrated under vacuum to provide 4-(chloromethyl)benzoyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756382B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-7cadaf82a2f04fe683c43460d0dc3fad |
| 出典メモ | uspto-grants-2004_06 |