Water → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

HRID 35386

反応式

HRID 35386 の反応式
[Cl:1][CH2:2][O:3][C:4](F)(F)[CH:5]([C:10]([F:13])([F:12])[F:11])[C:6]([F:9])([F:8])[F:7].O.S(=O)(=O)(O)[OH:18]>>[F:7][C:6]([F:9])([F:8])[CH:5]([C:10]([F:13])([F:12])[F:11])[C:4]([O:3][CH2:2][Cl:1])=[O:18]

参加物

4

反応物 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 138276951-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane

生成物 1

HCID 13954659Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate収率 101.1%

実験手順

In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol) and water (18.7 g, 1.04 mol) were charged, and concentrated sulfuric acid (74.8 g, 0.76 mol) was dropwise added thereto while stirring The reaction was continued at 110° C. for 20 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (187.8 g).

後処理

  1. additionwere charged
  2. distillationThen, the reaction mixture was distilled

出典と根拠

ORDレコード
ord-e4070553ddc946cb8b5dbbc6afa5647f
出典データセット
uspto-grants-1988_08
特許番号
US04766238

関連ノート

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