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Silica → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Silica | HCID 24261 | — |
| 反応物 | Fluorosulfuric acid | HCID 24603 | — |
| 反応物 | 1-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane | HCID 13827695 | — |
| 生成物 | Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate | HCID 13954659 | — |
反応手順
In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol), silicon dioxide and fluorosulfuric acid (70.0 g, 0.70 mol) were charged. The reaction was continued at 110° C. for 21 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (190.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766238 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-3e95dee8e9c04b8297e0607bbde36700 |
| 出典メモ | uspto-grants-1988_08 |