Triethylamine → 3,3,3-Trifluoro-2-(trifluoromethyl)-1-propene

温度

60 °C

In a four necked 100 ml flask equipped with a condenser, a dropping funnel and a thermometer, triethylamine (20.0 g, 198 mmol) was charged and warmed to 60° C. Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (4.88 g, 20 mmol) was dropwise added thereto while stirring. The reaction was continued at the same temperature as above for 2.5 hours while stirring. The gas evolved from a top of the condenser was washed with an alkaline solution, dried with alumina and cooled. The resultant liquid was distilled to give 2-trifluoromethyl3,3,3-trifluoropropene (2.36 g). Yield, 72 %.

1. customIn a four necked 100 ml flask equipped with a condenser, a dropping funnel
2. customwas continued at the same temperature as above for 2.5 hours
3. stirringwhile stirring
4. washwas washed with an alkaline solution
5. customdried with alumina
6. temperaturecooled
7. distillationThe resultant liquid was distilled

ORDレコード

ord-782b180886ab49749e0f4174bf616e31

出典データセット

uspto-grants-1988_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04766238