化工社化工社 化学情報印刷レポート · 研究参考用
Acetanilide → 2-Fluoro-N-phenylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetanilide | HCID 904 | — |
| 反応物 | N-(4-fluorophenyl)acetamide | HCID 9601 | — |
| 反応物 | Hypofluorous acid, trifluoromethyl ester | HCID 78989 | — |
| 反応物 | Acetamide, N-(2,4-difluorophenyl)- | HCID 96093 | — |
| 反応物 | N-(2,6-difluorophenyl)acetamide | HCID 138072 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Fluoro-N-phenylacetamide | HCID 9504 | 37% |
反応手順
A solution of 67.5 parts of acetanilide in 22,200 parts of chloroform was cooled to 0° C. and maintained at that temperature for 2.5 hours while fluoroxytrifluoromethane was bubbled into the solution at a rate of 46 parts per hour. Analysis of the reaction product by gas chromatographic technique indicated a 91 percent conversion with a yield of 37% 2-fluoroacetanilide, 16% 4-fluoroacetanilide, 10% 2,4-difluoroacetanilide, 3% 2,6-difluoroacetanilide and about 25% higher molecular weight material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766243 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-dd03a1401fc5494786ce532f55efd99a |
| 出典メモ | uspto-grants-1988_08 |