1,3-Benzenediacetonitrile → 2-[3-(2-Aminoethyl)phenyl]ethanamine
反応式
[C:1]1([CH2:10][C:11]#[N:12])[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1>CO.[Ni]>[C:3]1([CH2:7][CH2:8][NH2:9])[CH:4]=[CH:5][CH:6]=[C:1]([CH2:10][CH2:11][NH2:12])[CH:2]=1参加物
4
実験手順
To a solution of 1,3-phenylenediacetonitrile (9.37 g, 60 mmol) in CH3OH (saturated with NH3,150 mL) was added Raney-Ni (ca. 20 g, previously washed with CH3OH several times) and the mixture was hydrogenated at 45 psi on a Parr apparatus for 48 h. The reaction mixture was filtered through celite and the filtrate evaporated to give the crude product (9.45 g, 96%) as a light green oil: 1H NMR (CDCl3) δ 0.80-1.50 (br s, 4H), 2.70-2.76 (m, 4H), 2.94-2.99 (m, 4H), 7.01-7.07 (m, 3H), 7.18-7.26 (m, 1H). This was used in the next step without further purification.
後処理
- washpreviously washed with CH3OH several times) and the mixture
- filtrationThe reaction mixture was filtered through celite
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-70aaa5cdd28c41ae874829a47aea108a
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06756391B2
反応ノート
読み込み中…