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Pyridine → N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 2-(Aminomethyl)-4-tert-butylphenol hydrochloride | HCID 21296950 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide | HCID 13210348 | — |
反応手順
43 g (0.2 mole) of 2-aminomethyl-4-(1,1-dimethylethyl)-phenol hydrochloride are suspended in 400 ml of 1,4-dioxane, and 40 ml of pyridine are added. 40 ml (0.55 mole) of acetyl chloride are added dropwise while stirring and cooling with ice. The mixture is then stirred for 2.5 hours at 90° and poured into ice water, and the precipitate which has crystallized out is filtered off with suction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766241 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-961680e386e54d8096eab17a00cca646 |
| 出典メモ | uspto-grants-1988_08 |