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Methyl formate → Diethyl (5-formylfuran-2-yl)phosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl formate | HCID 7865 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | Phosphonic acid, 2-furanyl-, diethyl ester | HCID 12485182 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Diethyl (5-formylfuran-2-yl)phosphonate | HCID 46784019 | — |
反応手順
A solution of diethyl 2-furanphosphonate (1 mmole) in THF was treated with LDA (1.12 mmole, lithium N,N-diisopropylamide) at −78° C. for 20 min. Methyl formate (1.5 mmole) was added and the reaction was stirred for 1 h. Extraction and chromatography gave compound 1 as a clear yellow oil. Preferably this aldehyde can be prepared from 2-furaldehyde as described below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756360B1 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-e7ea51fa112449b7a3cf215aa3eb9143 |
| 出典メモ | uspto-grants-2004_06 |