関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisobutylaluminum hydride | HCID 14487 | — |
| 反応物 | Ethyl 2-((tert-butoxycarbonyl)amino)-1,3-thiazole-4-carboxylate | HCID 22280595 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester | HCID 22280475 | — |
反応手順
A solution of ethyl 2-[(N-Boc)amino]-4-thiazolecarboxylate (1 mmole) in CH2Cl2 (10 mL) was cooled to −78° C., and treated with DIBAL-H (1M, 5 ML). The reaction was stirred at −60° C. for 3 h, and quenched with a suspension of NaF/H2O (1 g/1 mL). The resulting mixture was filtered and the filtrate was concentrated to give 2-[(N-Boc)amino]-4-hydroxymethylthiazole as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06756360B1 |
|---|
| 出典データセット | uspto-grants-2004_06 |
|---|
| ORD ID | ord-e54be4ccf6624a928e5630811ab220bd |
|---|
| 出典メモ | uspto-grants-2004_06 |
|---|
