3-(Tert-butyldiphenylsiloxy)propanol → Propanal, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

HRID 354038

反応式

HRID 354038 の反応式
[Si:1]([O:18][CH2:19][CH2:20][CH2:21][OH:22])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl.C(OCC)C>[Si:1]([O:18][CH2:19][CH2:20][CH:21]=[O:22])([C:14]([CH3:16])([CH3:17])[CH3:15])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 102451343-(Tert-butyldiphenylsiloxy)propanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 9995679Propanal, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 3-(tert-butyl-diphenylsilyloxy)-1-propanol (1 mmole) in methylene chloride (7 mL) was treated with powder molecular sieves (4 A, 0.5 equiv. wt/wt) and pyridinium chlorochromate (1.5 mmole) at 0° C. The resulting mixture was stirred at room temperature for 2 h, and diluted with diethyl ether (7 mL) and stirred at room temperature for another 30 min. Filtration, evaporation and chromatography gave 3-(tert-butyldiphenylsilyloxy)-1-propanal as a clear oil.

後処理

  1. customat 0° C
  2. stirringstirred at room temperature for another 30 min
  3. filtrationFiltration, evaporation and chromatography

出典と根拠

ORDレコード
ord-78346f35d75e423bb45d1f572952c621
出典データセット
uspto-grants-2004_06
特許番号
US06756360B1

関連ノート

読み込み中…