Potassium Hydroxide → 4-(2-Chloroethoxy)benzoic acid
反応式
C[C:2]1[CH:10]=[C:9]([O:11][CH2:12][CH2:13][Cl:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[K+]>CO>[Cl:14][CH2:13][CH2:12][O:11][C:9]1[CH:10]=[CH:2][C:3]([C:4]([OH:6])=[O:5])=[CH:7][CH:8]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To methyl 4-(2-Chloroethoxy)-benzoic acid (11.8 gm, 53.5 mmol) dissolved in 118 mL of methanol was added 2N KOH (35mL, 1.3 equiv.) and the resulting solution was heated at 50° C. for 24 hrs. The reaction was cooled to room temperature and the methanol evaporated off. The residue was diluted with water and extracted once with ethyl acetate. The aqueous layer was then acidified with 6N HCl and a precipitate formed which was filtered off, washed well with water, and pumped dry under vacuum to yield 10 gm of the title compound.
後処理
- temperatureThe reaction was cooled to room temperature
- customthe methanol evaporated off
- additionThe residue was diluted with water
- extractionextracted once with ethyl acetate
- customa precipitate formed which
- filtrationwas filtered off
- washwashed well with water
- custompumped dry under vacuum
出典と根拠
- ORDレコード
- ord-d7372df631b542349a22e590570c18c4
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06756388B1
反応ノート
読み込み中…