Ammonia → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

HRID 35414ノート

反応式

HRID 35414 の反応式
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](Cl)(=[O:18])=[O:17])[C:8]=1[OH:20])=[O:4].[NH3:21]>CC(C)=O.O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](=[O:18])(=[O:17])[NH2:21])[C:8]=1[OH:20])=[O:4]

参加物

5

反応物 2

HCID 222AmmoniaHCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

生成物 1

HCID 132103556-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒

実験手順

33.8 g (0.1 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane are dissolved in a little acetone, and the solution is added dropwise to 50 ml of concentrated ammonia solution. The mixture is stirred for 30 minutes at room temperature and is diluted with water. The precipitate which is deposited is filtered off with suction and dissolved in acetone, and the solution is filtered and stirred into water again.

後処理

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. dissolutiondissolved in acetone
  3. filtrationthe solution is filtered
  4. stirringstirred into water again

出典と根拠

ORDレコード
ord-d94f91d0f9144c46a22b824f9bf58f64
出典データセット
uspto-grants-1988_08
特許番号
US04766241

反応ノート

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