化工社化工社 化学情報印刷レポート · 研究参考用
3-Chloro-2-methylanisole → 3-Chloro-o-cresol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-2-methylanisole | HCID 76749 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 3-Chloro-o-cresol | HCID 14856 | — |
反応手順
3.1 g (0.02 mol) of 3-chloro-2-methylanisole are heated in 20 ml of 50% sulphuric acid for 18 hours with reflux. After cooling, the reaction mixture is extracted three times with dichloromethane, dried over sodium sulphate and concentrated to dryness under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (2.9 g, content by HPLC: 11.7%, 12% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756512B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-4f149bc2b5f84728ba42e39fa0b4c854 |
| 出典メモ | uspto-grants-2004_06 |