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Hexane → Boc-L-Pro-Ome
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 溶媒 | Benzene methanol | HCID 21927730 | — |
| 生成物 | Boc-L-Pro-Ome | HCID 1277666 | 100% |
反応手順
To a stirred solution of the N-tert-butoxycarbonylproline (6.00 g, 0.0279 mol) in MeOH:benzene (1:4, v/v) was added dropwise 2.0 M-n-hexane solution of TMSCHN2 (16.7 mL, 0.0334 mol) at room temp. After the resulting solution was stirred for 1 hr at room temp, the mixture was evaporated off in vacuo to afford 6.39 g (100%) N-tert-butoxycarbonylproline methyl ester as a yellow syrup. 1H-NMR (CDCl3) δ1.41 (s, 9H), 1.85-1.98 (m, 4H), 2.21-2.28 (m, 2H), 3.72 (s, 3H), 4.29 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756378B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-9b482ae4f8e2409bab4080ac4c46c3e6 |
| 出典メモ | uspto-grants-2004_06 |