化工社化工社 化学情報印刷レポート · 研究参考用
2-Dimethylaminopyridine → N-Cbz-2-aminoisobutyric acid 2,2,5,5-tetramethylcyclopentyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 反応物 | N-((Benzyloxy)carbonyl)-2-methylalanine | HCID 294936 | — |
| 反応物 | 2,2,5,5-Tetramethylcyclopentan-1-ol | HCID 551696 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Cbz-2-aminoisobutyric acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 54425997 | — |
反応手順
To a stirred solution of 2 g (0.008 mol) of N-Cbz-2-aminoisobutyric acid in dry Cl(CH2)2Cl containing 1.9 g dicyclohexylcarbodiimide and 0.1 g dimethylaminopyridine (DMAP), all at 0° C., is added, via an addition funnel, 1.3 g of 2,2,5,5-tetramethylcyclopentanol dissolved in CH2Cl2. After stirring for 4 days, the mixture is filtered, and the filtrate is washed with 5% HCl (1×50 ml), saturated NaHCO3 (1×50 ml), and water (1×50 ml). The organic layer is separated, dried over MgSO4 and evaporated to yield N-Cbz-2-aminoisobutyric acid 2,2,5,5-tetramethylcyclopentyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766246 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-cbd23d7e09b84a9e80b24b274a0922b5 |
| 出典メモ | uspto-grants-1988_08 |