化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Amino-4-fluorobutanoic acid hcl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3-Boc-amino-4-fluorobutanoic acid | HCID 20508340 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Amino-4-fluorobutanoic acid hcl | HCID 86007272 | 68% |
反応手順
4-Fluoro-3-tert-butoxycarbonylamino-1-butanoic acid (545 mg, 2.46 mmoles) is dissolved in dry ether (20 ml) saturated with hydrogen chloride gas. After a few minutes, the solution becomes turbid and white crystals start to precipitate. Recrystallization from ethanol/ether afford beta-monofluoromethyl beta-alanine hydrochloride (265 mg, 68%), m.p. 152°-153° C. (dec).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04375477 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-eed7923475da4476acece2ab9d5f73eb |
| 出典メモ | uspto-grants-1983_03 |