1-Chloro-4-(4-chlorophenyl)butan-2-ol → 1-Chloro-4-(4-chlorophenyl)butan-2-one

HRID 354589ノート

反応式

HRID 354589 の反応式
[Cl:1][CH2:2][CH:3]([OH:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O.O>[Cl:1][CH2:2][C:3](=[O:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1

参加物

5

反応物 2

HCID 124320331-Chloro-4-(4-chlorophenyl)butan-2-olHCID 131709961Jones' reagent

生成物 1

HCID 128164651-Chloro-4-(4-chlorophenyl)butan-2-one収率 97.7%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒

実験手順

A solution of 1-chloro-4-(4-chlorophenyl)-2-butanol (125 g) in acetone (200 ml) at 0° C. was treated with 570 ml of Jones reagent (from sodium dichromate dihydrate (100 g), concentrated sulfuric acid (136 g) and water to 500 ml) and stirred overnight at room temperature. The resulting solution was diluted with water (200 ml), extracted with ether (3×300 ml) and the extracts washed with water, aqueous sodium bicarbonate, and dried (MgSO4). Evaporation of the ether gave 121 g of 1-chloro-4-(4-chlorophenyl)-2-butanone. The analytical sample from hexane had m.p. 65°-67° C.

後処理

  1. extractionextracted with ether (3×300 ml)
  2. washthe extracts washed with water, aqueous sodium bicarbonate
  3. dry with materialdried (MgSO4)
  4. customEvaporation of the ether

出典と根拠

ORDレコード
ord-864bb812126e4cc4b9f770d7b72f7ab3
出典データセット
uspto-grants-1983_03
特許番号
US04375474

反応ノート

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