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Chloroacetyl chloride → 6-(p-Chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 6-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one | HCID 676750 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 6-(p-Chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one | HCID 677107 | 81.4% |
反応手順
30.2 g (0.16 mole) of 6-(p-aminophenyl)-4,5-dihydropyridaz-3-one, 18.1 g (0.16 mole) of chloroacetyl chloride and 150 ml of absolute benzene are refluxed for 2 hours. The product is filtered off at room temperature, washed first with benzene and then with water, and dried under reduced pressure at 80° C. 34.6 g (81% of theory) of 6-(p-chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one are obtained as a beige solid which, after recrystallization from dimethylformamide/water, melts, with decomposition, at 233° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04376771 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-13c388ee19f04ac3b777292122a83c54 |
| 出典メモ | uspto-grants-1983_03 |