化工社化工社 化学情報印刷レポート · 研究参考用
Chloroacetyl chloride → beta-(p-Chloroacetylaminobenzoyl)-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 4-(4-Aminophenyl)-4-oxobutanoic acid | HCID 243290 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | beta-(p-Chloroacetylaminobenzoyl)-propionic acid | HCID 20507196 | 90.4% |
反応手順
20 g (103 millimoles) of β-(p-aminobenzoyl)-propionic acid and 12.9 g (114 millimoles) of chloroacetyl chloride, together with 200 ml of absolute toluene, are kept for 4 hours at 80° C. The product is filtered off at 10° C., washed with water and dried under reduced pressure at 50° C. 25.1 g (90% of theory) of β-(p-chloroacetylaminobenzoyl)-propionic acid are isolated as light brown crystals which, after recrystallization from acetone, melt at 184°-185° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04376771 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-da3c5c0beedc4de2ba281a95f4d9df2d |
| 出典メモ | uspto-grants-1983_03 |